SANTA CLARA, Calif. — Tom Brady threw for 280 yards and four touchdowns and the New England Patriots beat San Francisco 30-17 on Sunday in Brady’s first road game against the 49ers team he rooted for as a boy.

Brady found Danny Amendola for a 5-yard touchdown to start the fourth quarter then later hit Malcolm Mitchell on a 56-yard score for his fourth TD pass.

Brady also threw short touchdown passes to Julian Edelman and James White on his first two possessions and completed 24 of 40 passes. The AFC East-leading Patriots (8-2) bounced back from last week’s loss to the Seahawks on a rainy day at Levi’s Stadium.

With his 199th career victory, Brady tied Hall of Famer Brett Favre for second-most wins by a quarterback in NFL history. With his next win, Brady will match Peyton Manning for the top spot.

[naviga:h3]Redskins 42, Packers 24[/naviga:h3]

LANDOVER, Md. — Kirk Cousins went deep late and often, throwing for 375 yards and three touchdowns to lead Washington past free-falling Green Bay.

Cousins and the Redskins (6-3-1) have won six of their past eight games going into a showdown with the NFC East-leading Dallas Cowboys, the winners of nine in a row. The Packers (4-6) have lost four consecutive games and five of six, allowing 30 or more points in all of those defeats.

Robert Kelley ran for a career-best 137 yards and three touchdowns against a Green Bay defense that allowed completions of 70, 53 and 44 yards.

[naviga:h3]Seahawks 26, Eagles 15[/naviga:h3]

SEATTLE — Russell Wilson threw for 272 yards and a touchdown, and caught a 15-yard touchdown pass from Doug Baldwin and Seattle rolled past Philadelphia.

Wilson became the first quarterback in franchise history to catch a touchdown, a perfect end-around pass from Baldwin to Seattle’s athletic QB as he ran down the left sideline and dove into the end zone to give the Seahawks (6-2-1) a 23-7 lead.

[naviga:h3]Cowboys 27, Ravens 17[/naviga:h3]

ARLINGTON, Texas — Dak Prescott threw three touchdown passes, two to Dez Bryant, in the first game with Tony Romo as his backup, and the Cowboys set a franchise season record with their ninth straight win.

The Cowboys (9-1) punted on their first four possessions — a first this season — against the NFL’s No. 1 defense. They marched 92 and 88 yards on their first two drives of the second half to break a 10-10 tie. Both drives ended with TD passes to Bryant , who had six catches for 80 yards.

[naviga:h3]Vikings 30, Cardinals 24[/naviga:h3]

MINNEAPOLIS — Xavier Rhodes returned one of his two interceptions 100 yards for a touchdown and Cordarrelle Patterson took the second-half kickoff 104 yards for a score as the Vikings stopped their four-game losing streak.

The Vikings (6-4) used those momentum-shifting plays they’d been missing to hold onto a first-place tie with Detroit in the NFC North, with a rematch against the Lions looming in four days. After fueling a 5-0 start with four return touchdowns, the Vikings didn’t produce any over their last four games.

[naviga:h3]Dolphins 14, Rams 10[/naviga:h3]

LOS ANGELES — DeVante Parker caught a 9-yard touchdown pass from Ryan Tannehill with 36 seconds to play, and Miami rallied for two late scores to spoil Jared Goff’s NFL debut with a victory over Los Angeles.

Tannehill passed for 172 yards in the fifth straight victory for the Dolphins (6-4), who were dominated by the Rams’ defense until their final two drives on a rainy day at the Coliseum. Miami barely kept alive its longest winning streak since 2008.

After Jarvis Landry caught a 10-yard TD pass with 4:02 to play, the Dolphins got the ball right back and drove downfield for Parker’s diving TD reception in the corner.

[naviga:h3]Bucs 19, Chiefs 17[/naviga:h3]

KANSAS CITY, Mo. — Jameis Winston sliced up a Kansas City defense missing top cornerback Marcus Peters, and Tampa Bay snapped the Chiefs’ five-game winning streak.

Winston threw for 331 yards to help set up four field goals by Roberto Aguayo, and hit tight end Robert Cross for a touchdown with just over six minutes left to give the Buccaneers (5-5) a cushion.

[naviga:h3]Bills 16, Bengals 12[/naviga:h3]

CINCINNATI — LeSean McCoy ran 7 yards for a touchdown before suffering a thumb injury, for the Bills (5-5), who had lost three straight heading into their bye week.

Playing their first game in nearly a month at Paul Brown Stadium, the Bengals (3-6-1) couldn’t move the ball consistently or make an extra point. They also lost receiver A.J. Green to an injured right hamstring on the first pass of the game.

[naviga:h3]Giants 22, Bears 16[/naviga:h3]

EAST RUTHERFORD, N.J. — Eli Manning threw a go-ahead 15-yard touchdown pass to rookie Sterling Shepard in the third quarter as the Giants rallied for their fifth straight win.

Manning (21 of 36 for 227) also threw a third-quarter touchdown to Will Tye, Rashad Jennings scored on a 2-yard run and Robbie Gould kicked a 46-yard field goal.

[naviga:h3]Colts 27, Titans 17[/naviga:h3]

INDIANAPOLIS — Andrew Luck led the Indianapolis Colts to a big early lead, and the defense held on in the second half. Indianapolis (5-5) evened its record by winning back-to-back games for the first time this season.

And by earning their 11th straight victory in the series, the Colts climbed into second place in the AFC South.

Luck was 15 of 28 for 262 yards with two touchdowns and one interception as the Colts scored touchdowns on each of their first three possessions.

[naviga:h3]Lions 26, Jaguars 19[/naviga:h3]

DETROIT — Eric Ebron had a go-ahead 1-yard touchdown run early in the fourth quarter. Ebron’s first carry of his career, a handoff as he went from left to right after lining up as an off-the-line tight end, was set up by his career-long, 61-yard catch.

The Lions (6-4) have won five of six.