FOXBOROUGH, Mass. — The Buffalo Bills took advantage of sloppy, Tom Brady-less New England to hand the Patriots their first home shutout at Gillette Stadium, winning 16-0 on Sunday.

It was the first loss of the season for New England (3-1), which was playing its final game before Brady returns from his four-game “Deflategate” suspension. The Patriots, who moved into Gillette Stadium in 2002, were last blanked at home 6-0 by the New York Jets in 1993 at Foxboro Stadium.

Tyrod Taylor connected with LeSean McCoy for a 7-yard touchdown pass in the first quarter, Dan Carpenter added three field goals for Buffalo (2-2).

It was Buffalo’s second win in its last 16 visits to Foxborough. Including his tenure with the New York Jets, it gave Bills coach Rex Ryan his first regular-season road victory over Bill Belichick in eight tries. The last Bills’ shutout win away From Orchard Park was 23-0 over Washington in a Buffalo “home” game at Toronto on Oct. 30, 2011.

Cowboys 24, 49ers 17

SANTA CLARA, Calif. — Ezekiel Elliott ran for 138 yards and a touchdown and Dak Prescott threw for two scores to help the Cowboys overcome an early 14-point deficit to beat the 49ers.

The Cowboys (3-1) fell in a 14-point hole early in the second quarter before taking over the game behind a pair of rookies who have helped the team get off to a fast start this season with starting quarterback Tony Romo sidelined by a back injury.

Raiders 28, Ravens 27

BALTIMORE — Derek Carr threw four touchdown passes, the last to Michael Crabtree with 2:12 left.

After the Ravens rallied from a nine-point deficit in the fourth quarter to go ahead with 3 ½ minutes remaining, Carr directed a 66-yard drive that ended with a 23-yard strike to Crabtree in the back of the end zone.

Carr went 25 for 35 for 199 yards. Three of his TD passes went to Crabtree, who finished with seven catches for 88 yards to help Oakland (3-1) to its third road win.

Falcons 48, Panthers 33

ATLANTA — Matt Ryan shredded Carolina’s defense, passing for a team-record 503 yards and four touchdowns, Julio Jones had 12 receptions for a Falcons-record 300 yards. The totals by Ryan and Jones are the most ever allowed by Carolina.

One week after being held to one catch in a win at New Orleans, Jones had a 75-yard scoring catch late in the game as Atlanta solidified its early hold on the NFC South lead.

Broncos 27, Bucs 7

TAMPA, Fla. — Paxton Lynch made his NFL debut sooner than expected, stepping in for injured starter Trevor Siemian to help the Broncos remain unbeaten with a victory over the Buccaneers.

Siemian left the game with two minutes remaining in the first half with what the defending Super Bowl champions described as an injury to his left (non-throwing) shoulder. He remained in uniform and watched the second half from the sideline, wearing a baseball cap while Lynch — the 26th pick in this year’s draft— finished the Broncos’ ninth consecutive win.

Saints 35, Chargers 34

SAN DIEGO —Drew Brees led New Orleans to two touchdowns in the final 4 minutes, 50 seconds to rally the Saints to a stunning victory against Philip Rivers and the Chargers, who blew a 13-point lead by committing two crucial turnovers..

Brees overcome two interceptions to win in his return to San Diego, where he played his first five NFL seasons before being allowed to leave as a free agent. It was also the first win this season for the Saints (1-3).

After the final gun, Brees ran over to the stands and greeted Saints fans.

Rams 17, Cardinals 13

GLENDALE, Ariz. — Tavon Austin returned a punt 47 yards to set up Case Keenum’s 4-yard touchdown pass to Brian Quick with 2:41 to play, and the Rams improved to 3-1 for the first time in a decade with a victory over the Cardinals (1-3).

Arizona’s Carson Palmer threw for 288 yards and a touchdown but left the game to be evaluated for a concussion after his head slammed to the turf on a sack by Aaron Donald with 5:40 to play.

Jaguars 30, Colts 27

LONDON — Blake Bortles threw for two touchdowns and ran for another as Jacksonville held off a furious Indianapolis Colts rally for the Jaguars’ first win of the season. The victory at a raucous Wembley Stadium elevated Jacksonville into a tie with Indianapolis at 1-3 in the AFC South.

Andrew Luck led the Colts on three fourth-quarter touchdown drives to rattle the Jaguars’ nerves. But his fourth-and-1 pass at the Jacksonville 49 with 1:36 remaining fell from the hands of tight end Dwayne Allen to preserve the victory for under-fire Jaguars coach Gus Bradley.

Seahawks 27, Jets 17

EAST RUTHERFORD, N.J. — Russell Wilson was sharp and efficient despite playing with a sprained knee, throwing three touchdown passes.

Wilson injured the medial collateral ligament in his left knee last week against San Francisco and wasn’t his usual mobile self in this one, but his arm was plenty good. He finished 23 of 32 for 309 yards while wearing a brace on his leg as the Seahawks (3-1) won at MetLife Stadium for the first time since beating the Denver Broncos in the Super Bowl in 2014.

Jimmy Graham, questionable with back spasms earlier in the week, had six catches for 113 yards, including an impressive 17-yard one-handed grab in the opening quarter, while giving the Jets (1-3) fits all game.

Redskins 31, Browns 20

LANDOVER, Md. — Kirk Cousins threw three touchdown passes, including two to tight end Jordan Reed, and the Washington Redskins cashed in on several trips to the red zone.

The Redskins (2-2) scored four red zone touchdowns against the Browns (0-4) after going 3 for 14 in their first three games. Cousins connected with Reed for 8- and 9-yard touchdowns, Chris Thompson for a 5-yard score, and running back Matt Jones scored from 1 yard as part of his 117-yard performance.

Texans 27, Titans 20

HOUSTON — Will Fuller had a tiebreaking 67-yard punt return for a touchdown. It was the first time Houston (3-1) played without its star defensive end J.J. Watt since the 2010 season. Watt, out for the season after back surgery, had started 83 straight games since being drafted in 2011.

Fuller also had 81 yards receiving and a touchdown.

Tennessee (1-3) was driving with less than two minutes remaining, but Marcus Mariota’s pass to former Texan Andre Johnson on fourth down was broken up.

Bears 17, Lions 14 14

CHICAGO — Brian Hoyer threw for 302 yards and two touchdowns, and the Bears (1-3) got a win after starting 0-3 for the second time in as many seasons under coach John Fox.

They also stopped a six-game home losing streak as well as a six-game slide against Detroit (1-3), though things got tight near the end.

Chicago was leading 17-6 when Andre Roberts returned a punt 85 yards for a touchdown. Golden Tate then caught a 2-point conversion pass from Matthew Stafford to cut it to 17-14 with 1:52 left.

Hoyer was on target in his second straight start with Jay Cutler nursing a sprained right thumb. He was 28 of 36 passes against a defense missing the injured Ezekiel Ansah and DeAndre Levy.