SAN DIEGO— Japanese pitcher Kenta Maeda homered in the second at-bat of his major league debut with the Los Angeles Dodgers on Wednesday night and beat the Padres 7-0, making San Diego the first team in major league history to be shut out in its first three games.

The Padres were outscored 25-0 in the opening series against the Dodgers. They set the MLB mark with 27 straight scoreless innings to open a season. The old mark was 26 by the 1943 St. Louis Browns, according to STATS.

Yankees 16, Astros 6

NEW YORK — Starlin Castro homered and drove in five runs, Mark Teixeira had four RBIs and New York trounced Houston for its first victory of the season.

A’s 2, White Sox 1

OAKLAND, Calif. — Sonny Gray pitched seven strong innings, Mark Canha homered and Oakland got its first win of the season.

Gray, scratched from the opening-day start because of a stomach flu, gave up a run on three hits, walking four and striking out five.

Orioles 4, Twins 2

BALTIMORE — Chris Davis homered to back an effective pitching performance by Yovani Gallardo in his Orioles debut.

Nationals 3, Braves 1

ATLANTA — Pinch-hitter Matt den Dekker, recalled from the minors earlier in the day, had a tiebreaking, two-run double in a three-run seventh inning to help Washington complete an opening two-game sweep.

Stephen Strasburg (1-0), starting his final season with the Nationals before becoming eligible for free agency, allowed one run and six hits in six innings.

Rockies 4, D’Backs 3

PHOENIX — Rookie Trevor Story made baseball history by hitting a home run in each of his first three major league games and Colorado beat Arizona.

Story also is the first player in baseball history to hit a home run for each of his first four hits.

Indians 7, Red Sox 6

CLEVELAND — Mike Napoli homered against his former Boston teammates and Cleveland overcame David Ortiz’s second homer in his farewell season.

Reds 3, Phillies 2

CINCINNATI — Scott Schebler doubled with the bases loaded and one out in the ninth inning as Cincinnati took advantage of another meltdown by Philadelphia’s bullpen.

Tigers 7, Marlins 3

MIAMI — Jarrod Saltalamacchia homered and drove in four runs and Francisco Rodriguez struck out Giancarlo Stanton to end the game with the bases loaded as Detroit handed Miami ace Jose Fernandez his first loss in 27 career starts at home.

Mariners 9, Rangers 5

ARLINGTON, Texas — Robinson Cano homered twice and drove in five runs, including a two-run homer that capped Seattle’s five-run ninth.

Brewers 4, Giants 3

MILWAUKEE — Chris Carter hit his first home run for Milwaukee, then had a tiebreaking sacrifice fly in the seventh inning.

Jeff Samardzija, making his Giants debut after signing a $90 million, five-year contract, allowed three runs and eight hits in 5 1/3 innings, falling to 0-5 in 10 starts against Milwaukee.

Rays 5, Blue Jays 3

ST. PETERSBURG, Fla. — Steven Souza Jr.’s second home run of the game, a go-ahead, three-run drive in the eighth inning, lifted Tampa Bay over Toronto.