ARLINGTON, Texas — Matt Ryan and Julio Jones connected for two touchdowns, Devonta Freeman ran for 141 yards and three scores, and the Atlanta Falcons beat Dallas 39-28 Sunday in the Cowboys' first game without Tony Romo and Dez Bryant.

Freeman's third score early in the fourth quarter capped a rally from a trio of 14-point deficits for the Falcons (3-0), who didn't win their third game until Week 10 last year, and Week 13 in 2013.

Jones had his third straight 100-yard game to start the season, finishing with 164 and a clinching 2-yard score in the fourth quarter.

The Cowboys (2-1) had a six-game winning streak in the regular season snapped in backup quarterback Brandon Weeden's ninth straight loss as a starter.

Weeden completed his first 16 passes to start the season, but the run ended with a second-quarter interception that turned the game in the Falcons' favor.

Patriots 51, Jaguars 17

FOXBOROUGH, Mass. — Tom Brady became the fourth quarterback in NFL history to throw 400 touchdown passes, connecting for a pair of scores.

Brady completed a 1-yard TD pass to Danny Amendola in the second quarter and added a 13-yard touchdown to Keshawn Martin in the third. In all, Brady completed 33 of 42 passes for 358 yards.

Rob Gronkowski caught four passes for 101 yards for the Patriots (3-0). LeGarrette Blount ran for three 1-yard touchdowns.

It was the most points ever allowed by the Jaguars (1-2).

Broncos 24, Lions 12

DETROIT (AP) — Peyton Manning converted a fourth down with a 45-yard touchdown pass to Demaryius Thomas with 5 seconds left in the first half, and threw an 11-yard TD pass to Owen Daniels with 2:28 remaining.

The last time the Broncos (3-0) won their first three games was in 2013, when they reached the Super Bowl. The Lions (0-3) are off to their worst start since 2010, when they finished 6-10.

Seahawks 26, Bears 0

SEATTLE — Tyler Lockett returned the second-half kickoff 105 yards for a touchdown, Russell Wilson connected with Jimmy Graham on a 30-yard TD, and the Seahawks routed the undermanned Bears.

Seattle led just 6-0 at halftime after an offensive performance that led to a cascade of boos. Lockett started a huge second half as he went untouched on a perfectly executed return, the longest in franchise history. Later in the quarter, Wilson found Graham across the middle for his second touchdown catch this season.

Cards 47, 49ers 7

GLENDALE, Ariz. — Carson Palmer threw for 311 yards and Arizona returned two of Colin Kaepernick's first four passes for touchdowns.

Larry Fitzgerald caught nine passes for 134 yards and two touchdowns and Chris Johnson rushed for 110 yards and two scores for the Cardinals (3-0), who won at Chicago 48-23 last week.

Bills 41, Dolphins 14

MIAMI GARDENS, Fla. — Tyrod Taylor threw for 277 yards and three scores in his first NFL road start. The Bills totaled 429 yards, intercepted Ryan Tannehill three times in the first half, and led 27-0 before Miami scored late in the third quarter.

Texans 19, Bucs 9

HOUSTON — Ryan Mallett threw for threw for 228 yards and a touchdown and Alfred Blue had 139 yards rushing for Houston's first win of the season.

Mallett gave Houston (1-2) the lead on a 5-yard touchdown pass to DeAndre Hopkins on the opening drive. The Buccaneers (1-2) went up 9-7 on a TD catch by Charles Sims in the second quarter.

Eagles 24, Jets 17

EAST RUTHERFORD, N.J. — Darren Sproles returned a punt 89 yards for a score and added a 1-yard touchdown run for Philadelphia's first win.

Sam Bradford threw a TD pass to Ryan Mathews, who also rushed for 108 yards while starting in place of the injured DeMarco Murray.

Raiders 27, Browns 20

CLEVELAND — Derek Carr threw two touchdown passes, Latavius Murray rushed for 139 yards and Oakland snapped an 11-game road losing streak.

Carr connected with Andre Holmes and Seth Roberts in the first half and the Raiders (2-1) held off a late Cleveland comeback to win their first road game since Nov. 17, 2013.

Bengals 28, Ravens 24

BALTIMORE — Andy Dalton threw a 7-yard touchdown pass to A.J. Green with 2:10 left, and Cincinnati remained unbeaten. Baltimore dropped to 0-3 for the first time in franchise history.

The Bengals (3-0) blew a 14-0 lead and twice trailed in the fourth quarter.

Colts 35, Titans 33

NASHVILLE, Tenn. — Andrew Luck threw two touchdown passes 56 seconds apart in the fourth quarter as he rallied Indianapolis.

Luck improved to 7-0 against Tennessee with another stunning comeback. The Colts (1-2) trailed 27-14 before Luck got going. He drove the Colts 98 yards before hitting Phillip Dorsett on a 35-yard TD with 6:49 left.

Panthers 27, Saints 22

CHARLOTTE, N.C. — Cam Newton threw for 315 yards and a pair of touchdowns to tight end Greg Olsen and also ran for a score.

Vikings 31, Chargers 14

MINNEAPOLIS — Adrian Peterson plowed through San Diego's defense for 126 yards and two touchdowns on 20 rushes in three quarters. Chad Greenway scored on a 91-yard interception return.