NEW YORK — Alex Rodriguez homered for his 3,000th career hit and smiled all the way around the bases as the New York Yankees beat the Detroit Tigers 7-2 Friday night, the highlight so far in what has become a resurgent season for the formerly disgraced slugger.

Rodriguez wasted no time, connecting in the first inning on a first-pitch, 95 mph fastball from Tigers ace Justin Verlander (0-1).

Out of baseball last year while serving a drug suspension, Rodriguez became the 29th player in major league history to reach 3,000 hits. He was the first to do it since Yankees great Derek Jeter homered from the very same batter’s box in 2011.

Adam Warren (5-4) gave up two runs in a career-high eight innings, and Brett Gardner and Didi Gregorius also homered as the Yankees won their third in a row. Detroit has lost four of six.

Blue Jays 5, Orioles 4

TORONTO — Marco Estrada took a no-hitter into the eighth inning, Edwin Encarnacion had two RBIs and the Toronto Blue Jays won their ninth straight home game.

Batting for Steve Pearce, pinch-hitter Jimmy Paredes broke up Estrada’s no-hit bid with a bloop single to left to begin the eighth, ending a streak of 15 straight outs.

Rays 4, Indians 1

CLEVELAND — Asdrubal Cabrera hit one of three solo home runs for Tampa Bay in his return to Cleveland, leading the Rays over the Indians.

Cabrera, who played for the Indians from 2007 until being traded to Washington last July, broke a 1-all tie with a two-out homer in the second.

Joey Butler homered in the first inning and Steven Souza Jr. added a home run in the ninth for Tampa Bay, which has won seven of eight.

Rookie right-hander Nathan Karns (4-3) allowed one run in 5 1/3 innings for his first win since May 13. Four relievers followed with Brad Boxberger pitching the ninth for his 17th save.

Reds 5, Marlins 0

CINCINNATI — Mike Leake allowed only two singles through seven innings, and Marlon Byrd homered in his return from a broken wrist, leading the Cincinnati Reds over the Miami Marlins.

The Reds have won 10 of their last 13 against the Marlins. Miami has been held to four runs or less in each of their last 11 games against Cincinnati.

Leake (4-4) has a history of success against the Marlins, going 4-1 in five career starts. He retired the first 13 batters Friday before giving up two walks. Christian Yelich singled through the hole at shortstop with two outs in the sixth for Miami’s first hit.

Braves 2, Mets 1

ATLANTA — Matt Wisler allowed only one run in eight innings in his major league debut to outpitch Jacob deGrom, and Jace Peterson hit a two-run double in the eighth to lift the Atlanta Braves past the New York Mets.

Wisler (1-0) allowed one run and six hits and no walks in eight innings. The NL East-leading Mets’ only run off Wisler came on Michael Cuddyer’s run-scoring single in the sixth.

Twins 7, Cubs 2

MINNEAPOLIS — Phil Hughes held the Chicago Cubs to two hits over eight innings, Trevor Plouffe doubled twice and drove in four runs and the Minnesota Twins breezed to a victory to start their interleague series.

Anthony Rizzo homered twice for the Cubs. After his leadoff shot in the fourth, Hughes (5-6) retired the last 15 batters he faced.

Cardinals 12, Phillies 4

PHILADELPHIA — Randal Grichuk homered and had three hits, and Kolten Wong and Yadier Molina also went deep as the St. Louis Cardinals set season highs for runs and hits in a rout of the Philadelphia Phillies.

The Cardinals avoided their second three-game losing streak of the season while breaking out of the offensive funk that followed Tuesday’s news of a federal investigation into whether club officials illegally hacked into the Houston Astros’ player database. St. Louis pounded out 16 hits, including six for extra bases. Jhonny Peralta doubled and had three RBIs, Mark Reynolds had a two-run double and 10 Cardinals got hits.

Red Sox 7, Royals 3

KANSAS CITY, Mo. — Eduardo Rodriguez pitched capably into the seventh inning, Mookie Betts had a career-best four hits and the Boston Red Sox beat the Kansas City Royals.

Rodriguez (3-1), who gave up nine runs in 4 2/3 innings in his previous start against Toronto, allowed one run and six hits in 6 1/3 innings. Alcides Escobar’s RBI double in the fifth was the first run he allowed on the road in 18 1/3 innings.

Rangers 2, White Sox 1

CHICAGO — Pinch-hitter Mitch Moreland drove in two runs with a bases-loaded single off closer David Robertson in the ninth inning, and the Texas Rangers beat Chicago after getting dominated by White Sox starter Chris Sale.

Colby Lewis (7-3) pitched eight strong innings for Texas. But it looked like this was going to be Sale’s night until the late rally turned a promising night into the White Sox’s season-high eighth straight loss.

Angels 12, A’s 7

OAKLAND, Calif. — Albert Pujols hit a grand slam to highlight an eight-run seventh inning and drove in five runs, and the Los Angeles Angels rallied from five runs down to beat the Oakland Athletics.

Pujols hit his 20th home run of the season and 12th this month on a 1-1 pitch from reliever Edward Mujica (2-2), who was activated from the disabled list before the game. It was the 540th career home run for the Angels’ slugger and his 13th grand slam.

Brewers 9, Rockies 5

DENVER — Ryan Braun hit a two-run homer and Taylor Jungmann (2-1) threw six innings to help the Milwaukee Brewers snap a six-game losing streak.

Aramis Ramirez added a solo shot as the Brewers rediscovered the long ball after hitting only one homer in their losing streak. They had two off Jorge De La Rosa (4-3) in a three-run first inning.

D’backs 4, Padres 2

PHOENIX— Rubby De La Rosa (6-3) pitched seven strong innings and the Arizona Diamondbacks beat the San Diego Padres to hand James Shields his first loss of the season.

Arizona scored three runs in the third on doubles by David Peralta, Aaron Hill and Welington Castillo to go with Nick Ahmed’s single.

A fourth run was taken off the scoreboard when Paul Goldschmidt, originally ruled safe on a passed ball and tag play at home plate, was called out after a Padres challenge and replay review.

Mariners 5, Astros 2

SEATTLE — Roenis Elias settled down after a first-pitch home run, allowing four hits over seven-plus innings, and Mark Trumbo drove in three runs to pace the Seattle Mariners to a victory over Houston, ending the Astros’ five-game winning streak.

Elias (4-4), who had lost three of his previous four starts, gave up two runs — solo homers by George Springer and Marwin Gonzalez. He matched his career high with 10 strikeouts without a walk, but hit two batters.

Giants 9, Dodgers 5

LOS ANGELES — Buster Posey hit a grand slam and the San Francisco Giants got two RBIs each from Brandon Crawford and Matt Duffy in a win over the Los Angeles Dodgers.

The Giants’ eighth victory in 10 meetings with the Dodgers this season put the defending World Series champions within 1 1/2 games of NL West-leading Los Angeles.

Chris Heston (7-5) allowed three runs, seven hits and no walks over 5 2/3 innings in his second start since his no-hitter against the New York Mets on June 9.