The Houston Texans lost more than a game over the weekend — they lost outside linebacker Mario Williams for the season with a torn pectoral muscle.

Williams appeared to get hurt while sacking Oakland’s Jason Campbell with about five minutes left in the first quarter. He walked to the locker room on his own, and was on the sideline in the second half, wearing a T-shirt and shorts.

Coach Gary Kubiak said Monday that Williams will go on injured reserve and have surgery on the chest muscle.

The top overall pick in the 2006 draft, Williams moved from defensive end to outside linebacker this season in new coordinator Wade Phillips’ 3-4 alignment. He was growing into the role more each week, and had five sacks and a forced fumble before the injury.

The Texans fell to 3-2 after Sunday’s 25-20 loss to the Raiders.

Several other players will be out for a while after being injured Sunday.

Wide receivers Joshua Morgan of the 49ers and Donald Jones of the Bills, safety Kerry Rhodes of the Cardinals and left tackle Chad Clifton of the Packers all will miss significant time.

Morgan has a broken bone in his lower right leg that requires surgery. He was hurt late in the fourth quarter of San Francisco’s win over Tampa Bay.

“It’s more serious than what I thought after the ball game yesterday,” 49ers coach Jim Harbaugh said Monday. “Josh is going to be out for an extended time, longer than we anticipated and longer than we hoped — longer than you can afford to have him out.”

Jones will be out four to six weeks with a left ankle he sprained in the first quarter of Buffalo’s win over the Eagles. Bills defensive tackle Kyle Williams injured an ankle in the second half, and his status is uncertain for Sunday’s game against the Giants. Bills coach Chan Gailey ruled out starting left tackle Demetrius Bell (right shoulder) and starting outside linebacker Chris Kelsay (left calf). Both will miss their second straight game.

Jones is the third Bills receiver to be sidelined. The others — Roscoe Parrish (ankle) and Marcus Easley (chest) — are on injured reserve.

Rhodes broke his left foot in the Cardinals’ loss to Minnesota. Coach Ken Whisenhunt said Monday the injury is not season-ending but might require surgery.

Packers coach Mike McCarthy says Clifton has a “significant” hamstring injury, which occurred during Sunday night’s win over Atlanta.

McCarthy said it may be “a couple of weeks” before the Packers’ medical staff even knows the severity of the injury.

Clifton was bowled over by Falcons defensive end Ray Edwards in the second quarter and remained on the turf, clutching his right leg. He had to be helped to the sideline and then was carted to the locker room.

Chris Johnson didn’t finish the Titans’ loss at Pittsburgh because of some tightness in a hamstring, but Tennessee has a bye week and coach Mike Munchak said Johnson should be able to play against Houston on Oct. 23. Rookie linebacker Colin McCarthy hurt a hamstring, as well.