INDIANAPOLIS — The Indianapolis Colts thought they’d suffered a big blow when they ruled their four-time MVP quarterback out for the season opener. Now they may have lost Peyton Manning for the entire season.

Manning underwent more neck surgery Thursday, his third procedure in 19 months, and his return this season is uncertain.

Losing Manning for any stretch of time is something the Colts would love to avoid, and it’s certain to throw the race for the AFC South wide open. Manning hasn’t missed a game in 14 NFL seasons, with 227 consecutive starts, including the postseason.

“Rehabilitation from such surgery is typically an involved process,” the team said in a statement, calling the procedure “uneventful.”

The Colts said there would be “no estimation of a return date at this time. We will keep Peyton on the active roster until we have a clear picture of his recovery process.”