Big Papi has morphed into Big Puny.

The fall of Boston Red Sox designated hitter David Ortiz hit Romanesque proportions Wednesday when he went 0-for-7 at the plate, struck out three times and left 12 runners on base.

Ortiz has been the DNH — designated no-hitter.

The Red Sox have since benched the anti-slugger.

Ortiz is batting .208, has not homered this season and has gone 144 at-bats without trotting around the bases.

His last home run came Sept. 22 at Fenway Park. The pitcher who served up perhaps the final home run of Ortiz’s career?

Seneca Valley graduate Zach Jackson.

If Ortiz is hoping to face Jackson again, he may have to wait awhile — or not.

Jackson has already taken a ride on the Tribe’s ongoing pitching conveyer belt between Cleveland and Columbus, so the only way Big Puny, er, Papi will get a chance to mash against the SV lefty again is if he is sent down to Pawtucket.

Don’t rule it out.

The Red Sox can join the trend these days of finding obscure ailments for struggling players so they can ship them to the minor leagues on a rehab assignment to get them out of their funk.

The Yankees placed pitcher Chien-Ming Wang on the disabled list after he was lit up like Butler's main street in December with “hip abductor muscle weakness,” which is medical mumbo-jumbo for “inflammation of the ERA.”

And Detroit Tigers pitcher Dontelle Willis hit the DL with “Steve Blass flu.”

So, what ailment could the Sox blame Ortiz’ woes on?

How about “Juan Pierre Syndrome.”