Even without Tony Romo, the Dallas Cowboys were expected to beat the St. Louis Rams.

Peyton Manning and the Indianapolis Colts were supposed to have an easy time with a Green Bay Packers defense missing two starters in the secondary.

It didn't work out that way for either team, both losing 34-14 on the road Sunday.

With Romo watching from the sidelines due to a broken right pinkie, 40-year-old backup Brad Johnson couldn't keep up with the Rams' suddenly potent and opportunistic offense.

Steven Jackson ran for 160 yards with three touchdowns, and the Rams (2-4) won their second straight game under new coach Jim Haslett. Their defense did its part, too, forcing four turnovers for the second straight game.

"It's just the will of the players, more than anything," Haslett said. "I thought they played extremely well today, in all three phases."

At Lambeau Field, safeties Nick Collins and Aaron Rouse both ran interceptions back for long touchdowns to help the Packers (4-3) win their second straight after a three-game skid.

"I can't really give you one simple answer, try to summarize what's going on," said Manning, who finished 21-of-42 for 229 yards. "We just need to play better. I need to play better and find a way to get into the end zone. Our offense needs to try to get the lead to help our defense out a little bit. We didn't do our job."

Romo, who broke his finger in last week's loss at Arizona, looked fine throwing in pregame warmups with his hand wrapped. The Cowboys originally believed the injury would sideline him a month, but held out hope Romo could play until game day.

After warmups, he told the coaching staff he wasn't up to it.

Indianapolis (3-3) is off to its worst start since 2001 — the last time the Colts didn't make the playoffs. Coach Tony Dungy said he couldn't remember a sloppier performance during his time with the team.

"It's a very, very disappointing game, obviously," Dungy said. "It's the way we've been all year. We've been up and down, not consistent, and we showed more of that today. They played smarter and sharper than we did."

The Packers, missing injured cornerback Al Harris and safety Atari Bigby, got another strong game from quarterback Aaron Rodgers. Gutting out his third straight game with a sprained right shoulder, Rodgers was 21-for-28 for 186 yards and a touchdown despite 30-mph wind gusts.

Running back Ryan Grant added his first 100-yard game of the season, carrying 31 times for 105 yards and a touchdown.

At Chicago, Kyle Orton threw two touchdown passes and the special teams chipped in with two more in a rout of Minnesota.The Bears (4-3) intercepted Gus Frerotte four times even though its injury-riddled secondary was missing starting cornerbacks Nathan Vasher and Charles Tillman and nickel back Danieal Manning.

Sebastian Janikowski bailed out Oakland coach Tom Cable in his home debut as head coach, hitting a team-record 57-yard field goal with 2:30 left in overtime.The game only went to the extra period because Cable called a late timeout that negated Jay Feely's missed 52-yard field goal in the final seconds. Feely made good on his second attempt.

At Orchard Park, N.Y., Trent Edwards went 25-of-30 for 261 yards and a touchdown, and Kawika Mitchell intercepted a pass from Philip Rivers at the goal line to thwart a go-ahead score.

Jeff Garcia completed 26 of 37 passes for 310 yards, including a 47-yard touchdown pass to Antonio Bryant on Tampa Bay's opening drive.Garcia helped the NFC South-leading Bucs (5-2) improve to 4-0 at home.

Clinton Portis broke a scoreless tie with a 3-yard run in the third quarter and finished with 175 yards on 27 carries, and Santana Moss spun his way to an 18-yard touchdown reception in the fourth quarter as the Redskins (5-2) won for the fifth time in six games.

LenDale White rushed for three touchdowns and 149 yards, including an 80-yard sprint, and Chris Johnson unfurled a 66-yard gallop while rushing for 168 yards to lead visiting Tennessee.

Owen Daniels scored two touchdowns and rookie Steve Slaton and Ahman Green added a touchdown each for host Houston. Andre Johnson had 11 receptions for 141 yards for his third straight 100-yard game, and the Texans (2-4) scored touchdowns on their first three possessions for the first time in team history.

Brandon Jacobs ran for two touchdowns, Eli Manning threw for another, and Michael Johnson had two interceptions as the Giants (5-1) won their fourth straight at home.San Francisco (2-5) turned over the ball three times, allowed six sacks and had 13 penalties for 134 yards en route to its fourth straight loss.

Jake Delhomme threw for 195 yards and two touchdowns, Jonathan Stewart rushed for another score and Carolina's defense shut down visiting New Orleans.

Former Miami coach Cam Cameron, now Baltimore's offensive coordinator, orchestrated four scoring drives against the team he coached to only one win last year.Joe Flacco threw for 232 yards and Terrell Suggs scored on a 44-yard interception return, and Baltimore held Ronnie Brown to 27 yards.