Take away a few of his weapons and all Peyton Manning does is lead a rout anyway.

Operating without standout receiver Marvin Harrison and running back Joseph Addai — not to mention defensive starters safety Bob Sanders and linebackers Rob Morris and Freddy Keiaho — Manning guided a clock-eating Indianapolis offense to a 33-14 romp over Tampa Bay.

Kenton Keith ran for two touchdowns and 121 yards in his first NFL start and Manning threw for two more scores as the Colts (5-0) headed into their bye week unbeaten for the third straight season.

That allowed the Colts to keep pace with New England, which beat Kansas City 34-17, atop the AFC. Green Bay fell from the unbeaten ranks when it lost at home to Chicago 27-20.

Dallas, which plays Monday night at Buffalo, is the other unbeaten club.

At Indianapolis, the Colts kept the ball for 38:15 and limited the Bucs (3-2) to 8 yards rushing and 74 yards in offense in the first three quarters, 56 on Tampa's only meaningful scoring drive.

Tom Brady threw for three touchdowns, tying an NFL record with at least three in each of his first five games. Junior Seau grabbed two interceptions, and New England became the first team to start a season with five wins by at least 17 points.

At Green Bay, the Bears (2-3) took advantage of five turnovers by the Packers, who lost for the first time in five games.

At Denver, the Chargers (2-3) handed the Broncos their worst home loss since 1966. Reigning MVP LaDainian Tomlinson gained 140 total yards and backup Michael Turner added 147 yards on 10 carries — highlighted by a 74-yard touchdown trot along the Broncos' bewildered sideline in the fourth quarter.

John Kasay made a 52-yard field goal as time expired as he dropped New Orleans to 0-4. Kasay made six field goals in the Superdome against the Saints in 2004.

At Houston, Kris Brown kicked five field goals, including the winner on a career-long 57-yarder with 1 second remaining. Brown tied an NFL single-game record with three makes over 50 yards. He hit two 54-yarders earlier in the game for the Texans (3-2).

At St. Louis, the Cardinals (3-2) lost starting QB Matt Leinart to a broken collarbone. So Kurt Warner produced three touchdowns in his former home.

The Redskins (3-1) held the ball and wore down the Lions on a hot day to keep alive a 70-year hex for Detroit in the nation's capital: the Redskins are 21-0 at home against the Lions since they moving to Washington.

Vincent Fuller picked off a pass and returned it 76 yards for a touchdown, and Kyle Vanden Bosch sacked Byron Leftwich with 1:01 left.

At San Francisco, Ray Lewis, Ed Reed and the defense suffocated San Francisco (2-3) on all but a few plays. Matt Stover made up for Baltimore's near-equal offensive ineptitude with three field goals.

The visiting Jaguars (3-1) held the Chiefs to 10 yards rushing. The Jaguars, who gave up 282 yards rushing to Tennessee in losing their opener, have not allowed more than 48 yards on the ground in any of the three games since, all wins.

Rookie Aaron Ross returned the second of his first two NFL interceptions 43 yards for a touchdown with just over 3 minutes remaining.