Site last updated: Monday, April 29, 2024

Log In

Reset Password
MENU
Butler County's great daily newspaper

Antibiotics, C-sections may affect bacteria in baby's guts

Intestinal bugs aid more than just digestion

WASHINGTON — Two new studies are offering some of the clearest snapshots yet of how babies build up protective gut bacteria, adding to evidence that antibiotics and birth by C-section may disrupt that development.

Intestinal bacteria are underappreciated. They do far more than help digest food — they also play roles in the immune system. The types and amounts of gut bacteria that people harbor are thought to influence obesity, digestive diseases, even autoimmune disorders such as asthma and allergies.

But very little is known about how babies first develop their own unique set of bugs, what’s called the gut microbiome. Wednesday’s studies closely tracked infants through toddlerhood and concluded that the first two to three years of life are a critical period for budding microbiomes.

Still, “what happens when you don’t have the right bugs at the right age during that critical period? We don’t know the answer,” cautioned Dr. Martin Blaser of New York University, who led one of the studies.

Using monthly stool samples to track changes in gut bacteria, Blaser’s team studied 43 U.S. infants for two years after birth, and a team at Massachusetts General Hospital and the Broad Institute tracked 39 Finnish children to age 3.

Repeated use of antibiotics in childhood diminished the diversity of bacteria believed to be part of a healthy microbiome, concluded both studies, published in the journal Science Translational Medicine.

Children’s microbiomes gradually mature to more resemble those of adults, and Blaser found antibiotic treatment delayed that maturation. The Mass General team also found antibiotics made tots’ microbial communities less stable and triggered a temporary rise in genes that can make germs become antibiotic-resistant.

The average U.S. child receives three courses of antibiotics by age 2, and public health officials are working to reduce unnecessary antibiotics — when they’re prescribed for things such as ear or respiratory infections without checking whether a virus, which antibiotics can’t treat, really is the culprit.

Researchers have long known that C-section babies harbor different gut bacteria early on than vaginally delivered infants who were exposed to their mother’s germs in the birth canal. The new studies detail how those babies bear a particular microbial signature characterized by lower levels of bugs from the Bacteriodes family that plays a role in intestinal immunity. Antibiotics had an even greater effect on youngsters who lacked those bugs.

More in Community

Subscribe to our Daily Newsletter

* indicates required
TODAY'S PHOTOS