NASHVILLE, Tenn. — Marcus Mariota turned in a clean performance in his home debut, Tennessee cornerback Perrish Cox returned an interception 24 yards for a touchdown and the Titans beat St. Louis 27-14 on Sunday night to spoil Rams coach Jeff Fisher’s return to town.

A week after Mariota was sacked, threw an interception and lost a fumble that was returned for a touchdown, the No. 2 pick overall out of Oregon was 5 of 8 for 58 yards with no turnovers.

Titans teammate Dexter McCluster dropped Mariota’s pass in the end zone, while Rams safety Mark Barron couldn’t hold a would-be interception off the rookie.

Fisher, the winningest coach in Tennessee history after more than 15 seasons, was honored with a video tribute during the first timeout in the first quarter, and he acknowledged a standing ovation with a wave.

49ers 23, Cowboys 6

SANTA CLARA, Calif. — Long black hair swinging from his helmet, 303-pound defensive lineman Mike Purcell intercepted Dustin Vaughan’s pass and returned it 37 yards for a touchdown to help San Francisco beat Dallas.

Purcell, a practice-squad player in 2013 and for all but the final two games last season, provided the highlight again after his six-tackle day last week in an opening loss at Houston.

Dallas quarterback Tony Romo’s day was done after one three-and-out series then the Cowboys turned to Brandon Weeden, who left with a possible head injury.

Craig Dahl also added an interception for San Francisco.