INDIANAPOLIS — Denver quarterback Brock Osweiler ran for one touchdown and threw for two more Thursday night to lead the Broncos past Indianapolis 25-13.

Osweiler replaced the injured Trevor Siemian in the first quarter and played his best football of the season.

The Broncos (5-10) needed it. After ending an eight-game losing streak Sunday, they picked up their first road win since Dec. 4, 2016.

For Indianapolis (3-11), it was more of the same. The Colts blew an early 10-0 lead and have now lost five in a row, the longest skid of coach Chuck Pagano’s six-year tenure.

Osweiler looked more like the player Denver envisioned when it drafted him in the second round in 2012, and the guy who filled in for an injured Peyton Manning during the Broncos’ 2015 Super Bowl season.

He was 12 of 17 with 194 yards and took the Broncos on three second-half scoring drives — giving the league’s top-rated defense more than enough points.

C.J. Anderson ran 30 times for a season high 158 yards.