TAMPA, Fla. — Quinton Flowers threw for 280 yards and four touchdowns and No. 22 South Florida returned from a Hurricane Irma-imposed layoff to rout Illinois 47-23 on Friday night.

Flowers moved ahead of Matt Grothe and B.J. Daniels into second place on USF’s career touchdown pass list with 53. The 2016 American Athletic Conference offensive player of the year also scored his 32nd rushing touchdown, tying Marlon Mack’s school record.

The Bulls (3-0) beat a Big Ten opponent for the first time on a night USF honored first responders who worked the past week to help victims of the massive storm that impacted the entire state of Florida.

Illinois (2-1) stumbled in what also was a homecoming of sorts for coach Lovie Smith, who returned to the stadium where he led the Tampa Bay Buccaneers for two seasons before being fired and accepting the challenge of rebuilding the Illini.

Illini freshman Mike Epstein scored on a 46-yard run and a 21-yard pass from Jeff George Jr., who replaced starter Chayce Crouch in the second half.

Flowers completed 15 of 25 passes, including TD throws of 39 yards to Deangelo Antoine, 17 yards to Marquez Valdes-Scantling, 17 yards to D’Ernest Johnson and 13 yards to Tyre McCants. Flowers also scored on a 6-yard run on the last play of the first half and finished with a team-best 106 of USF’s 376 yards rushing.

Johnson and Darius Tice joined Flowers in topping 100 yards rushing, with USF amassing 680 yards total offense to Illinois’ 354.