NEW ORLEANS — Drew Brees passed for 465 yards and four touchdowns, Wil Lutz kicked a 52-yard field goal with 11 seconds left, and the New Orleans Saints pulled out a 41-38 victory over the Carolina Panthers on Sunday.

With his 15th 400-yard game, Brees broke a tie with Peyton Manning for the most in the regular season.

Brees also led the Saints (2-3) to a second straight victory while Carolina lost its fourth straight despite the return of quarterback Cam Newton, who missed last week’s loss to Tampa Bay because of a concussion.

Newton passed for 322 yards and two touchdowns. He also ran for a 2-yard score and threw a 2-point conversion to Devin Funchess that tied the game at 38 with 2:58 left, and completed a comeback from an early 21-0 deficit.

Cowboys 30, Packers 16

GREEN BAY, Wis. — Rookie Dak Prescott threw for 247 yards and three touchdowns, and the Cowboys forced four turnovers.

Prescott was 18 of 27, shaking off two fumbles and an interception — the first of his career — to lead the Cowboys (5-1) to their fifth straight win. He showed poise in the fourth quarter while marching the Cowboys on a seven-play, 75-yard drive that ended with a 4-yard touchdown pass to Cole Beasley for an 18-point lead.

Seahawks 26, Falcons 24

SEATTLE — Steven Hauschka’s 44-yard field goal with 1:57 remaining capped the 20th career fourth quarter or overtime comeback for Seattle quarterback Russell Wilson.

After watching Matt Ryan blitz the Seahawks for 21 third-quarter points, it was Wilson’s turn in the fourth quarter. He led a 70-yarddrive that was capped by Christine Michael’s 1-yard run with 4:47 left, but a blocked extra point by Ra’Shede Hageman still had Seattle trailing 24-23.

Chiefs 26, Raiders 10

OAKLAND, Calif. — Spencer Ware ran for a career-high 131 yards and a touchdown and Alex Smith picked apart Oakland’s struggling defense.

In their first game since getting blown out by 29 points in Pittsburgh two weeks ago, the Chiefs (3-2) efficiently handled a Raiders team that had overcome defensive shortcomings with a big-play offense to lead the AFC West.

Smith completed 19 of 22 passes for 224 yards, Jamaal Charles and big defensive lineman Dontari Poe each ran for scores, and the Chiefs forced two turnovers by Derek Carr to dampen a fast start to the season by the Raiders (4-2), who are trying to end a 13-year playoff drought.

Texans 26, Colts 23

HOUSTON — Nick Novak made a 33-yard field goal in overtime to give Houston a comeback victory over Indianapolis.

Brock Osweiler threw a 36-yard pass to Jaelen Strong to get Houston to the 12 and Novak’s field goal came two plays later. Indianapolis (2-4) got the ball first in overtime, but Benardrick McKinney sacked Andrew Luck on third down to force a punt.

Redskins 27, Eagles 20

LANDOVER, Md. — Kirk Cousins threw for 263 yards and two touchdowns and the Redskins ran roughshod over one of the NFL’s top defenses.

The three-headed running attack of Matt Jones, Robert Kelley and Chris Thompson combined for 231 yards and a touchdown as the Redskins (4-2) won their fourth consecutive game. After starting the season 0-2, Washington has its best record through six games since 2008, when it went 8-8.

Bills 45, 49ers 16

ORCHARD PARK, N.Y. — LeSean McCoy scored three times and the Bills extended their winning streak to four. McCoy had 140 yards rushing and shook off what appeared to be a frightening injury to his right knee late in the second quarter.

Tyrod Taylor threw two touchdown passes in helping Buffalo (4-2) win four straight for the first time since the start of the 2008 season.

Colin Kaepernick provided the 49ers a spark in his first start in nearly a year. Blaine Gabbert was benched following a 33-21 loss to Arizona, and Kaepernick finished 13 of 29 for 187 yards, including a 53-yard touchdown pass to Torrey Smith. But San Francisco (1-5) couldn’t finish drives, settling for three field goals by Phil Dawson, in losing its fifth straight game.

Patriots 35, Bengals 17

FOXBOROUGH, Mass. — Playing in his first game in Foxborough since the end of his “Deflategate” suspension, Tom Brady had three touchdown passes and went over 5,000 completions for his career.

Brady finished 29 for 35 for 376 yards. Tight end Rob Gronkowski had seven receptions for a career-high 162 yards and a touchdown.

Cincinnati dropped to 2-4 for the first time since 2010, when it finished 4-12 — its worst season under coach Marvin Lewis.

The Bengals had their moments offensively, scoring on a 2-yard touchdown run by Andy Dalton and 5-yard pass from Dalton to Brandon LaFell. But New England (5-1) bounced back from some sluggish drives early with several big plays in the third quarter.

Giants 27, Ravens 23

EAST RUTHERFORD, N.J. — A banged-up Odell Beckham Jr. turned a short fourth-and-1 pass into a winning 66-yard catch and run with 1:24 to play as the Giants snapped a three-game losing streak.

The win was the 700th in franchise history. Beckham gave it to the Giants with a career day despite going to the locker room with a hip pointer in the second quarter. Beckham returned before the half and made the Giants (3-3) a winner with a spectacular second half. It featured a 75-yard touchdown catch and a 43-yard reception that set up one of Josh Brown’s two field goals.

The Ravens (3-3) lost their third straight.

Beckham finished with eight catches for 222 yards. His late heroics saved the Giants, who were on the verge of a fourth straight loss after Terrance West scored on a 2-yard run with a 2:04 to play, giving the Ravens a short-lived 23-20 lead.

Lions 31, Rams 28

DETROIT — Matt Prater made a tiebreaking, 34-yard field goal with 1:29 left and Rafael Bush followed with a victory-sealing interception two plays later. The Lions (3-3) have won two straight games with Prater making the winning kick and a defensive back following up with an interception on the ensuing possession.

The Rams (3-3) have lost two straight.

Case Keenum completed a Rams-record 19 straight passes, but couldn’t connect with Lance Kendricks on the long throw that Bush stepped in front of near midfield. Keenum finished 27 of 32 for 321 yards with three touchdowns — two to Kenny Britt, one to Kendricks — and an interception.

Titans 28, Browns 26

NASHVILLE, Tenn. — Marcus Mariota threw for 284 yards and three touchdowns, and the Titans got their second straight victory — the first time they’ve won consecutive games since the end of the 2013 season.

The Titans (3-3) matched their win total for all of last season when they went 3-13 and wound up with the No. 1 draft pick overall. They also beat a team other than Jacksonville on their own field for the first time since the 2013 season finale and improved to 3-16 in Nashville.

Cleveland (0-6) is mired in its worst start since 1999 when the Browns lost their first seven as an expansion franchise.

Jaguars 17, Bears 16

CHICAGO — Blake Bortles threw for 271 yards and hit a slipping Arrelious Benn for a 51-yard touchdown in the closing minutes.

The Jaguars (2-3) wiped out a 13-0 deficit in the fourth quarter in a matchup of last-place teams. And the go-ahead touchdown might have been helped by the oft-criticized turf at Soldier Field.