CINCINNATI — Trevor Siemian threw a career-high four touchdown passes in his first road start and was nearly perfect under fourth-quarter pressure, rallying Denver over Cincinnati, 29-17, Sunday.

The defending Super Bowl champions are 3-0 under Siemian, who took over after Peyton Manning retired and Brock Osweiler went to Houston. He completed 11 of 12 passes while rallying the Broncos to a pair of fourth-quarter touchdowns.

The previous Bronco to throw for four touchdowns was Manning in 2014 against the Dolphins. Siemian went 23 of 35 for 312 yards and a passer rating of 132.1.

[naviga:h3]Packers 34, Lions 27[/naviga:h3]

GREEN BAY, Wis. — Aaron Rodgers threw for 205 yards and four touchdowns, including two in the first half to Jordy Nelson, and Green Bay snapped out of its offensive funk before holding off Detroit.

[naviga:h3]Cowboys 31, Bears 17[/naviga:h3]

ARLINGTON, Texas — Dak Prescott led scoring drives on all four Dallas possessions in the first half before throwing his first career touchdown pass, and the Cowboys beat Chicago to snap an eight-game home losing streak.

With his second straight win, Prescott doubled the number of victories the Cowboys (2-1) had in 14 games without injured quarterback Tony Romo over three seasons before the rookie fourth-round pick showed up. Prescott was 19 of 24 for 248 yards in Dallas’ first home win since last year’s opener.

[naviga:h3]Vikings 22, Panthers 10[/naviga:h3]

CHARLOTTE, N.C. — Sam Bradford threw a touchdown pass to Kyle Rudolph, Marcus Sherels returned a punt for a score and Minnesota snapped Carolina’s 14-game home winning streak.

Seahawks 37, 49ers 18

SEATTLE — Russell Wilson threw for 243 yards and a touchdown before suffering a left knee injury and Seattle rolled to a rout of San Francisco.

[naviga:h3]Colts 26, Chargers 22[/naviga:h3]

INDIANAPOLIS — Andrew Luck shook off a sore throwing shoulder, then watched T.Y. Hilton break a tackle on a 63-yard touchdown pass with 1:17 to play, giving Indianapolis a victory over San Diego.

It’s the second time this season Luck has produced a late score to give Indy a lead in the waning seconds.

[naviga:h3]Redskins 29, Giants 27[/naviga:h3]

EAST RUTHERFORD, N.J. — Dustin Hopkins kicked a 37-yard field goal late in the fourth quarter for his fifth of the game and Washington Redskins avoid a near-disastrous 0-3 start with a win over the penalty-and error-prone New York.

[naviga:h3]Rams 37, Bucs 32[/naviga:h3]

TAMPA, Fla. — Case Keenum threw for the Rams’ first touchdown since relocating back to Los Angeles, and Todd Gurley rushed for two more scores in a victory over Tampa Bay.

[naviga:h3]Chiefs 24, Jets 3[/naviga:h3]

KANSAS CITY, Mo. — Kansas City Chiefs returned two turnovers for touchdowns, intercepted three passes in the end zone and forced eight turnovers total in a victory over New York.

[naviga:h3]Ravens 19, Jaguars 17[/naviga:h3]

JACKSONVILLE, Fla. — Justin Tucker kicked a 54-yard field goal with 1:02 remaining, lifting Baltimore over Jacksonville.

[naviga:h3]Bills 33, Cardinals 18[/naviga:h3]

ORCHARD PARK, N.Y. — LeSean McCoy scored twice and safety Aaron Williams returned a botched field-goal snap 53 yards for a touchdown in leading Buffalo over Arizona.

[naviga:h3]Raiders 17, Titans 10[/naviga:h3]

NASHVILLE, Tenn. — Derek Carr threw for 249 yards and a touchdown, and Oakland beat Tennessee with its defense finally coming up with big plays.

[naviga:h3]Dolphins 30, Browns 24[/naviga:h3]

MIAMI GARDENS, Fla. (AP) — Jay Ajayi scored on an 11-yard run with 8:26 left in overtime, and Miami escaped with a win over Cleveland.

Ryan Tannehill threw for 319 yards and three touchdowns for Miami.