VATICAN CITY — Pope Francis issued a blistering critique today of the Vatican bureaucracy that serves him, denouncing how some people lust for power at all costs, live hypocritical double lives and suffer from “spiritual Alzheimer’s” that has made them forget they’re supposed to be joyful men of God.

Francis’ Christmas greeting to the cardinals, bishops and priests who run the Holy See was no joyful exchange of holiday good wishes. Rather, it was a sobering catalog of 15 sins of the Curia that Francis said he hoped would be atoned for and cured in the New Year.

He had some zingers: How the “terrorism of gossip” can “kill the reputation of our colleagues and brothers in cold blood.” How cliques can “enslave their members and become a cancer that threatens the harmony of the body” and eventually kill it by “friendly fire.” About how those living hypocritical double lives are “typical of mediocre and progressive spiritual emptiness that no academic degree can fill.”

“The Curia is called on to always improve itself and grow in communion, holiness and knowledge to fulfill its mission,” Francis said. “But even it, as any human body, can suffer from ailments, dysfunctions, illnesses.”

Francis, who is the first Latin American pope and never worked in the Italian-dominated Curia before he was elected, has not shied from complaining about the gossiping, careerism and bureaucratic power intrigues that afflict the Holy See. But as his reform agenda has gathered steam, he seemed even more emboldened to highlight what ails the institution.

The cardinals were not amused. The speech was met with tepid applause, and few were smiling as Francis listed one by one the 15 “Ailments of the Curia” that he had drawn up, complete with footnotes and Biblical references.

The Vatican’s finances are also in the midst of an overhaul, with Francis’ finance czar, Cardinal George Pell, imposing new accounting and budget measures on traditionally independent congregations not used to having their books inspected.